Actually, it seems that the name comes from the reference to the Chapitoulas Indians or River People, a tribe who inhabited the area dating back to the 1500′s. Plantations were established along the river in the 1700′s by French Settlers and one was called “Tchoupitoulas”. We were able to trace the information from the following references.
From a State Marker along hwy 48 near Destrehan:
Tchoupitoulas Plantation is acquired by Joseph Soniat du Fossat. Visited by Governor William C. C. Claiborne and, legend says, privateer Jean Lafitte. Chapitoulas Indians, whose name means river people, lived in this area of Destrehan in Jefferson Parish.
From the History of New Orleans
published by The Lewis Publishing Company,
Chicago and New York, 1922
Among the earliest thoroughfares in the upper part of the city (New Orleans) was Tchoupitoulas Road — the Chemin de Tchoupitoulas, or “fish hole” road, which led up the river to Bayou Tchoupitoulas. This was originally an Indian path (named after the Chapitoulas Indians who cut the path along the river for trade).